Histopathological and Immunohistochemical Study of Peri-Implant Epithelium

Background: Human beta-defensins (HBDs), epithelial-derived antimicrobial peptides, contribute to gingival health and periodontal disease. Particularly, the upregulation of HBD-3 expression in tissues is described tissue regeneration. Specifically, But there has been insufficient investigation inner epithelium peri-implantitis, especially HBD patterns as protection against oral infection. Objectives: The purpose this study was investigate histopathological characteristics implant peri-implantitis using immunohistochemical methods compare it with marginal periodontitis. Materials Methods: biopsied cases consisted 10 11 periodontitis, controls. HE observation, measurement thickness epithelium, analysis for Ki-67 were conducted. Results: Concerning significantly higher periodontitis (156.2 [138.0, 186.4] μm) than control, 70.7 [67.5, 97.5] μm 80.7 [76.6, 89.4] μm, respectively (p < 0.001). positivity rates, both outer following order: control elevated case For HBD-3, intensity region score (IRS) (superficial layer) 0.001) all cases. comparisons IRS, values seen that Conclusion: Decreased production keratinocytes composing may be one factors affecting repair peri-implantitis.